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You can propagate pothos very easily by using plain potting soil. It can take 4-6 weeks for your Pothos cutting to develop roots when you plant it in soil.
When you choose to use water propagation for your Pothos, it will grow roots quicker than other methods. On average, you should see roots starting to grow between the first 7-14 days.
When propagated in moss or perlite, your Pothos will develop roots within a month. Perlite and peat moss (sphagnum moss) provide a good balance of moisture and oxygen, so the roots will develop quickly and remain healthy.